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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of retinoblastoma (RB)
ncRNA name hsa-miR-30c-2*
ncRNA Category miRNA
Disease name retinoblastoma (RB)
Species Homo sapiens
Tissues/Cell_line human RB cell line HXO-RB44
Methods microarray, qRT-PCR
Expression pattern up-regulated
Functional description We identified a cluster of miRNAs that includes miR-181b, miR-125a-3p, miR-30c-2, miR-497 and miR-491-3p as hypoxia-regulated miRNAs (HRMs) in retinoblastoma cells. Functionally, these HRMs are involved in apoptosis, cell adhesion, cell proliferation and mRNA processing, all processes that associate closely with the hypoxia response of cancer cells.
PubMed ID 21373755
Year 2011
Title Microarray-based analysis: identification of hypoxia-regulated microRNAs in retinoblastoma cells.
Drug-related ncRNA NO

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